The Olympic champion, who reached his eighth consecutive Super 1000 final, dispatched his unseeded opponent in just 38 minutes to claim his second straight tournament in Jakarta following his success at the Indonesian Masters one week ago.
Axelsen overcame Malaysia's star Lee Zii Jia in a thrilling semifinal on Saturday and from Monday will overtake India's Lakshya Sen to top the men's singles World Tour rankings.
Earlier in the day, Tai Tzu Ying of Chinese Taipei saw off Asian champion Wang Zhi Yi of China to win her third women's singles crown at the tournament (after titles in 2016 and 2018).
The Tokyo 2020 silver medallist narrowly lost the first game (21-23) but immediately reacted by taking the second period 21-6.
Tai, who will turn 28 on Monday, took control of the decider and saw off Wang 21-15 to clinch her second consecutive title in the BWF World Tour after the Thailand Open.
The finals day had started with the success of China's Zheng Si Wei and Huang Ya Qiong, who earned the mixed doubles title after seeing off Watanabe Yuta and Higashino Arisa of Japan in two games (21-14, 21-16).
Matsuyama Nami and Shida Chiharu of Japan retained their Indonesia Open women's double crown after coming back from one game down against compatriot Fukushima Yuki and Hirota Sayaka.
In the men's doubles final Liu Yu Chen and Ou Xuan Yi capped off an impressive campaign after being promoted from the reserves list as they defeated Korea's Choi and Kim in two games.
Find all the results below.
Indonesia Open 2022: Finals - Results
Mixed doubles: Zheng Si Wei-Huang Ya Qiong (CHN) beat Watanabe Yuta-Higashino Arisa (JPN) 21-14, 21-16
Women's singles: Tai Tzu Ying (TPE) beat Wang Zhi Yi (CHN) 21-23, 21-6, 21-15
Women's doubles: Matsuyama Nami-Shida Chiharu (JPN) beat Fukushima Yuki-Hirota Sayaka (JPN) 18-21, 21-14, 21-17
Men's singles: Viktor Axelsen (DEN) beat Zhao Jun Peng (CHN) 21-9, 21-10
Men's doubles: Liu Yu Chen-Ou Xuan Yi (CHN) beat Choi Sol Gyu-Kim Won Ho (KOR) 21-17,
Indonesia Open 2022: How to watch
The Indonesia Open 2022 is being shown globally, with broadcast partners in each region.
Fans in Malaysia can watch Lee Zii Jia live on Astro's subscription channels.
And if you are unable to find a screen to watch the matches, look out for Olympics.com's match reports from the Istora Senayan in Jakarta.