Just one year on from winning five gold medals at the Tokyo 2020 Olympics, all eyes will be on the 25-year-old to see if he can reproduce those heroics.
Katie Ledecky will once again headline the women’s events, but both Florida-based athletes will need to be at their best to hold off the latest crop of exciting youngsters coming through the American system.
The action takes place April 26-30 at North Carolina’s Greensboro Aquatic Center, with the top two finishers in each individual event being selected for the World Championships in Budapest, Hungary from June 17-July 3.
Below, we take a look at the key storylines, schedule, and stars to look out for.
Athletes to watch
Katie Ledecky underlined her status as swimming’s distance queen at Tokyo 2020, winning her sixth and seventh Olympic gold medals in the 800m and 1500m freestyle.
She continues to dominate the 200, 400, 800 and 1500 free domestically too, having not lost in any of those events to another American in eight years.
The 17-year-old breakout star, who made her Olympic debut in Tokyo, is the fastest athlete in the US this year over the 50 and 100 free, 50 and 100 back, and 100 fly.
As a North Carolina native, she will be in home water at Trials and will be looking to put down a marker before Budapest.
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Caeleb Dressel is arguably the biggest name in world swimming right now, thanks to his breathtaking performances at Tokyo 2020.
The sprinting sensation has yet to find his best form in 2022, notably finishing behind his compatriots in several events at this year’s Pro Swim Series, but typically saves his best form for the biggest meets. For that reason, he will go into trials as the favourite in both freestyle sprints and the 100m butterfly.
One man Dressel will have his eye on is Shaine Casas. After missing out on Olympic selection, the 22-year-old Texan has taken 2022 by storm and leads the national rankings in the 100 free, 100 fly and 200 IM.
Another versatile talent to watch closely is Michael Andrew. He ranks No. 1 nationally in the 50m freestyle and 100m breaststroke this season with Michael Phelps recently said in an interview that Andrew can break the 200 IM world record with some small training adjustments.
US Swimming World Trials Schedule
Heats begin each day at 09:00 EDT (GMT-4) with finals starting at 18:00 EDT
Tuesday 26 April
200 Butterfly W-M
100 Freestyle W-M
Women’s 800 Freestyle
Men’s 1500 Freestyle
Wednesday 27 April
200 Freestyle W-M
200 Breaststroke W-M
200 Backstroke W-M
50 Butterfly W-M
Thursday 28 April
400 Individual Medley W-M
100 Butterfly W-M
50 Breaststroke W-M
50 Backstroke W-M
Friday 29 April
400 Freestyle W-M
100 Breaststroke W-M
100 Backstroke W-M
Saturday 30 April
Women’s 1500 Freestyle
200 Individual Medley W-M
Men’s 800 Freestyle
50 Freestyle W-M
Details on how to buy tickets for the event can be found here.