Tatyana McFadden's dominance in the Paralympic 1500m wheelchair race was ended on Tuesday (31 August 2021).
The American was beaten into fifth in the 1500m T54 final, after a searing race in a stacked field.
Fourth place belonged to Merle Menje from Germany, 0.4s behind De Rosario, with McFadden fifth timing 3:28.85.
Zhou backs up qualifying performance with win
The 23-year-old Zhou had warned of her intentions in the heats a day earlier, when she came second to McFadden in their qualifier, finishing just 0.16s behind her U.S. rival.
The American was aiming for a 1500m threepeat following gold medal performances at Rio 2016 and London 2012, and missing out on the podium means she remain on 19 Paralympic medals.
When is Tatyana McFadden competing next at Tokyo 2020 Paralympics in 2021?
Tatyana McFadden will be back on track at the Tokyo 2020 Paralympics on Thursday 2 September from 12:42 JST in the women's 400m T54 heats.
Her remaining Paralympic events in Japan are:
Women's 400m T54 - Thursday 2 September with heats starting at 12:42 and the final, if she makes it, at 19:40.
Women's marathon T54 - Sunday 5 September 06:40. (All times JST)