The Malaysian duo dispatched England's Chloe Birch and Lauren Smith 21-5, 21-8 in front of a capacity crowd at Birmingham's NEC.
Despite huge home support from the stands, Tan and Muralitharan raced to an opening game victory in around 20 minutes.
The shot of the game came when Muralitharan skilfully returned a shuttle through her legs while on the backfoot, before going on to win the point.
It was more of the same in the second game, with the Birch and Smith unable to live with their opponents' superior skill and power.
Muralitharan was able to pull off a few more trick shots, much to the Malaysian fans' huge delight, as they wrapped up the game and match.
The victory secured a second gold medal for Tan and Muralitharan at Birmingham 2022, after they helped Malaysia to victory in the mixed team event last week.
For Smith, it's a second silver medal of these Games after she finished second in the mixed doubles alongside Marcus Ellis. It's also her fifth Commonwealth silver overall, having won silver in the same two events in Gold Coast, and the mixed team silver at Glasgow 2014.
"No words can describe how we feel right now. We're really really happy," Muralitharan said after.
"Thanks to all the supporters that made us feel at home," Tan added.