The 36-year-old Swiss, who has an Olympic medal of each colour, held off Spain's David Valero to further underline his reputation as the greatest mountain bike racer of all time at the scene of his world junior triumph back in 2004.
Ferrand-Prevot, meanwhile, stamped her authority on the women's race from the start, to add to her short track title from Friday.
"It's unbelievable. I couldn't believe it when I crossed the finish line that I did it again." - Nino Schurter
Ferrand-Prevot blitzes rivals to regain women's title
The course in Les Gets was a challenging one with a gruelling climb right at the start.
Starting 20th on the grid, home favourite Ferrand-Prevot moved through the field and attacked within the first three-quarters of a kilometre.
After the first lap of six, she had established a 22-second lead on the pack. By the end of lap two, she was a minute clear with Batten and Alessandra Keller of Switzerland leading the chasers.
Ferrand-Prevot, who took the short track title on Friday, continued to push the pace at the front with Neff moving past team-mate Keller and Batten into second place.
Reigning world champion Evie Richards had to stop to change a shoe which ended the Briton's slim medal hopes. She eventually finished in 11th.
On the penultimate lap, Keller lost touch to leave Neff and Batten to fight it out for silver with the French leader almost two minutes clear.
And Ferrand-Prevot just kept going, celebrating with a couple of corners to go before crossing the line 1:35 ahead of Neff.
Ferrand-Prevot told UCI afterwards, ""I wanted to go straight from the start, to go full gas and to try to make a gap. I made it and I can't believe it. It's like a dream. I think there will be a big party tonight."
2022 UCI Mountain Bike World Championships - Women's Elite Cross-country results:
1. Pauline Ferrand-Prevot (FRA) 1:22:08
2. Jolanda Neff (SUI) +1:35
3. Haley Batten (USA) +2:13
4. Loana Lecomte (FRA) +3:27
5. Alessandra Keller (SUI) +3:46
6. Anne Terpstra (NED) +4:09
7. Mona Mitterwallner (AUT) +4:24
8. Malene Degn (DEN) +4:36
9. Caroline Bohe (DEN) +4:53
10. Annie Last (GBR) +5:12
Schurter surges to 10th world title
Olympic champion Pidcock was the man everyone feared in a sensational 2022 in which he has won the cyclo-cross world crown, the famous Alpe d'Huez stage on the Tour de France, and the European mountain bike cross-country title last week.
Friday's short track winner Sam Gaze suffered an early crash on a down slope with the New Zealander holding his wrist as he walked away.
Midway through the seven-lap distance, Pidcock - who won both MTB World Cup events he contested early in the season - made his move to the front with Braidot and Schurter trying to stay with him before the Swiss slid off on an inocuous grassy right-hander.
Schurter was able to make ground again with Sarrou and Hatherly losing touch as Valero took a turn on the front.
On lap four, Pidcock took something of a breather as Valero pushed the pace with Schurter and Braidot keeping tabs.
Pidcock soon regained contact with the front three but then Schurter launched a big attack at the end of lap five with Valero the only man able to go with him.
A crash and rear-wheel change saw Pidcock lose further time to leave Braidot safe in third place. But it was all about the duel for gold.
And in the closing kilometre, Schurter made his decisive break to clinch yet another honour in his spectacular career.
He told UCI afterwards, ""It was a tough race. I really tried to take it over from the start, make it a hard race.
"In the end it was Valero and I and I took my chance to try to force him to make mistakes and luckily he made a mistake in one of the last technical bits. And from there, I went full gas and I still can't believe it."
As if to further underline his greatness, Schurter is the oldest rider to win a mountain bike world title, with his junior success in 2004 making him the youngest as well.
2022 UCI Mountain Bike World Championships - Men's Elite Cross-country results:
1. Nino Schurter (SUI) 1:21:13
2. David Valero (ESP) +0:09
3. Luca Braidot (ITA) +0:29
4. Tom Pidcock (GBR) +1:29
5. Marcel Guerrini (SUI) +1:40
6. Jordan Sarrou (FRA) +2:04
7. Alan Hatherly (RSA) +2:11
8. Victor Koretzky (FRA) +2:37
9. Filippo Colombo (SUI) +2:49
10. Ondrej Cink (CZE) +2:51