Fraser-Pryce, who missed the last Diamond League women's 100m in Paris at the end of August after withdrawing with fatigue, looked back on form at the World Continental Gold event as she set a meeting record of 10.81 to take the 100m, breaking 11 seconds for the 12th time this season.
The 34-year-old looks set for an exciting rematch with Olympic champion Elaine Thompson-Herah in the Zurich Diamond League Final on Thursday.
Tokyo 2020 200m gold medallist De Grasse was an easy winner of the half-lap event, coming off the bend strongly to cross the line in front in 20.21.
Fellow Canadian Jerome Blake was second in 20.32 with Italy's sprint relay hero Filippo Tortu third in 20.40.
As befits the competition held in memory of the Sydney 2000 hammer gold medallist, field events played a big part in the Continental Tour Gold meeting.
The top three in the men's hammer in Tokyo filled the top three places in Chorzow but in different places.
The Olympic gold medallist led with 77.45m, but Fajdek went out to 79.60m to take victory after his bronze in Japan.
Norway's Eivind Henriksen (77.38m) was third after his Tokyo silver.
Double Olympic champion Ryan Crouser took his unbeaten run to 25 contests with victory in the shot put.
The American was not at his brilliant best but 22.39m in round two was enough to take victory with compatriot Joe Kovacs (22.00m) and New Zealand's Tom Walsh (21.68m) second and third just as they were in Tokyo.
World record holder Crouser suffered his last defeat at the 2019 Doha World Championships.
Olympic silver medallist Chris Nilsen kept up his strong recent form with 5.86m to take victory in the men's pole vault.
Reigning world champion Sam Kendricks was only sixth with a best clearance of 5.70m.
Gianmarco Tamberi won the high jump with a third-time success at 2.30m.
The Italian then failed with two attempts at 2.36m which would have broken the meet record held by joint-Olympic gold medallist Mutaz Essa Barshim.
After disappointment in Tokyo and second place in Paris, Johannes Vetter returned to winning ways in the javelin.
With no 'Final 3' as in the Diamond League, the German's second-round effort of 89.60m was enough to see him avenge last weekend's defeat to Grenada's world champion Anderson Peters (83.61m).
There was a home win in the women's event with Olympic silver medallist Maria Andrejczyk setting a meeting record of 61.77m in the fifth round.
Michael Cherry has been in excellent form since just missing out on the individual 400m podium in Tokyo.
Fresh from clocking a new personal best of 44.03 in Brussels on Friday night, the Olympic relay gold medallist surged clear off the home bend and coasted over the line in 44.94.
The Nigerian, who was fourth in Tokyo, was a comfortable winner in 12.64 with Tapper crossing the line in 12.75 ahead of Christina Clemons.
Britain's Jemma Reekie won the women's 1000m in a new meet record
Alison dos Santos backed up his win in Friday's Brussels Diamond League with a meeting record of 48.50 in the 400m hurdles.
Brazil's Olympic bronze medallist was three-tenths clear of Yasmani Copello of Turkey with Jamaica's Jaheel Hyde third.
Italy's Elena Vallortigara took some notable scalps as she equalled her season's best of 1.96m to take the high jump. Ukraine's Iryna Herashchenko, fourth in Tokyo, was second with 1.94m ahead of home jumper Kamila Licwinko and another Ukrainian, Yuliya Levchenko, who both cleared 1.91m.
Not even a personal best for Tokyo steeplechase gold medallist Soufiane El-Bakkali was enough to give him victory in the flat 3000m.
The Moroccan was beaten by Ethopian teenager Tadese Worku who clocked a meeting record 7:36.47 two weeks after his gold at the World U20 Championships in Nairobi. El-Bakkali ran 7:37.18 with compatriot Mohammed Tindouft third.
And finally, there was an emotional farewell for two-time Olympic silver medallist Piotr Malachowski in the men's discus.
The retiring 38-year-old threw a best of 62.29m to finish fourth, with Slovenia's Olympic finalist Kristjan Ceh winning with a best throw of 66.65m.
It was an extra special competition for Malachowski, whose seven-year-old son Henryk von-Engel-Malachowski also taking part in the event, recording 24.36m with his best throw.